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品系编号 T000047
品系名称 B6;129-Mylktm1/Nju
曾用名
品系简称
品系来源
健康报告 -
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入库时间 2010-07-27
相关基因 MLCK
品系类型 CKO
背景 B6;129
对照鼠
提供基因型 (Mylk)fln/wt;(Mylk)mut/mut;(Mylk)mut/wt
毛色 灰色;黑色
引入代数
当前代数
繁育方式 (Mylk)fln/wt X [J000664] C57BL/6JNju
保存方式 冷冻
平均单胎产仔量 0
建议繁殖笼淘汰周期
母性
品系描述

ENSMUSG00000022836;国家支撑计划项目,排他使用期已过,产权归属于国家遗传工程小鼠资源库。 此品系的表型数据请参考列出的“文献”。风险提示:NRCMM获得杂合子即进行了冷冻,并未进行进一步繁育和表型分析验证。所以无法对文献中的数据进行保证。

研究领域 自主知识产权小鼠
应用
参考文献

1. Wei-Qi He, Yan-Ning Qiao, Ya-Jing Peng, Juan-Min Zha, Cheng-Hai Zhang, Chen Chen, Cai-Ping Chen, Pei Wang, Xiao Yang, Chao-Jun Li, Kristine E. Kamm, James T. Stull, Min-Sheng Zhu. Alteration of contractile phenotypes of intestinal smooth muscle from mice deficient in myosin phosphatase target subunit 1. Gastroenterology (revised).
2. Wei-Qi He, Yan-Ning Qiao, Cheng-Hai Zhang, Ya-Jing Peng, Chen Chen, Pei Wang, Yun-Qian Gao, Caiping Chen, Xin Chen, Tao Tao, Xiaohong Su, Chaojun Li, Kristine E. Kamm, James T. Stull and Min-Sheng Zhu. Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension Am. J. Physiol. Heart Circ. Physiol. 2011;301(2):H584-91.
3. Wen-Cheng Zhang, Ya-Jing Peng, Gen-Sheng Zhang, Wei-Qi He, Yan-Ning Qiao, Ying-Ying Dong, Yun-Qian Gao, Chen Chen, Cheng-Hai Zhang, Wen Li, Hua-Hao Shen, Wen Ning, Kristine E. Kamm, James T. Stull, Xiang Gao and Min-Sheng Zhu. Myosin light chain is necessary for tonic airway smooth muscle contraction. J Biol Chem 2010; 285:5522-5531
4. Wei-Qi He, Ya-Jing Peng, Wen-Cheng Zhang, Ning Lv, Jing Tang, Chen Chen, Cheng-Hai Zhang, Song Gao, Hua-Qun Chen, Gang Zhi, Robert Feil, Kristine E. Kamm, James T. Stull, Xiang Gao and Min–Sheng Zhu. Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 2008; 135:610-620
5. Smith, L., et al., Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo. J Biol Chem, 2002. 277(38): 35597-604
6. Zhang, W.C., et al., Identification and functional characterization of an aggregation domain in long myosin light chain kinase. FEBS J, 2008. 275(10): 2489-500
7. Zhu, G.J., et al., Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells. PLoS One, 2012. 7(4): e34894.
8. Yu, Y., et al., Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide-induced increase in microvascular endothelium permeability in mice. FEBS J, 2012. 279(8): 1485-94
9. Chen, C., et al., Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism. J Biol Chem, 2014. 289(41): 28478-88.
9. Wang, Y., et al., Molecular and cellular basis of the regulation of lymphatic contractility and lymphatic absorption. Int J Biochem Cell Biol, 2014. 53: 134-40.
10. Liang, Q.X., et al., Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod, 2015. 92(4): 97.
11. Chen, C.P., et al., In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol, 2015. 593(3): 681-700.
12. Zhang, C.H., et al., The molecular basis of the genesis of basal tone in internal anal sphincter. Nat Commun, 2016. 7: 11358.

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